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Understanding N-Acetyl-L-Glutamate Synthase Deficiency: Mutational Spectrum, Impact of Clinical Mutations on Enzyme Functionality, and Structural Considerations

These dual effects reverse the immunosuppressive tumor microenvironment, thereby facilitating enhanced immune surveillance and a more robust antitumor immune response

doi: 10.1016/j.cell.2019.03.032 14 WuJRTuoQZLeiP

Actinobacteria , one of the largest phyla within the domain Bacteria, comprises spore-forming bacteria with a high GC content in their genomes

Materials and methods Samples collection and ethical approval A total of 20 paraffin-embedded CRC primary tumor samples were obtained from the Department of Pathology of Nanfang Hospital, Southern Medical University, Guangzhou, China