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doi: 10.3389/fimmu.2022.891822 [DOI] [PMC free article] [PubMed] [Google Scholar] 223.Liu K, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, et al

116,117 In the early stages of tumor development, the immune microenvironment mainly suppresses tumor proliferation through the cytokine environment produced by activated CD8+ and CD4+ T cells