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Metabolism in enterocytes of the small intestine and in the colonocytes is important not only for energy production but also for intracellular signaling and inter-organ relationships

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Experiments have demonstrated that TCM formulas have significant efficacy in regulating the balance of pro-inflammatory and anti-inflammatory factors, reducing the level of oxidative stress, regulating autophagy and apoptosis, repairing the intestinal mucosal barrier, and regulating the balance of intestinal microorganisms, which are achieved by modulating the PI3K/Akt signaling pathway (Supplementary Table 2)

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