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Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders

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2021 Feb;21(2):161

These reports emphasize that pharmacological intervention in FA metabolism has therapeutic benefit

Notably, the basal levels of these cytokines were substantially higher in HFD mice compared to RD counterparts, whereas the inhibitory effect of POSTN deletion was consistently observed across both dietary conditions (Supplementary Fig

Collectively, these data show that DMF constitutes an attractive compound for the pharmaceutical industry for drug repurposing in other neurodegenerative diseases ( TABLE 1 DMFs ability to alleviate pathological hallmarks of AD, PD and ALS in pre-clinical models in the context of Nrf2 activation