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10.1371/journal.ppat.1004033 39

KapoorTSNavinyaCAnuragGLokhandePRathiSGoelAet al

In relation to histamine, methylation is required for the HNMT enzyme (which breaks down histamine in the brain) and COMT enzyme (which detoxifies oestrogen in the liver)

The injectable versus oral peptide comparison is also relevant here, because some researchers transitioning from oral semaglutide may have different GLP-1 receptor adaptation profiles than those coming from injectable formulations