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Statements Author contributions XL drafted the manuscript by reviewing the literature

They are often designed to improve the bioavailability of active drugs by increasing their amount in target cells and reducing off-target effects

The potential mechanisms of action are summarized in Figure 3

A single infusion of CAR-T cells has been shown to delay T1D onset in NOD mice

It is not just inflammation that is involved in the development of neurodegeneration, but also several factors that interact amongst themselves and that include mitochondrial damage, which is closely related to oxidative stress 8,9

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