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Lu, W., Wang, L., Chen, L., Hui, S

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These MIMPs may further act as target of clinical therapy for IBD patients (Yin et al., 2018)

Quantification of gene expression by quantitative PCR Messenger RNA for the pro-oxidant enzymes, the NOX enzymes ( Nox1 , Nox2 , p47 phox , Nox4 ), for the vascular endothelial growth factor-A ( Vegf-a ), for the antioxidant redox enzymes, heme oxygenase 1 ( Ho-1 ), and glutathione peroxidases 1 ( Gpx1 ), for the cytokines, Tnf- , IL-1 , superoxide dismutase type 2 ( Sod2 ), and for the nitric oxide synthase (NOS) isoforms, eNos , iNos , and nNos , was quantified in the whole retinal explants as described before [39]

Glutathione is the body's most abundant natural antioxidant

Fast metabolizers process caffeine quickly, often experiencing milder effects and requiring higher doses to achieve the same stimulation as slow metabolizers, who may feel pronounced effects from smaller amounts