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That observation was reproduced in these experiments (Figure 2)

However, although multiple TCMs and NPs have shown promising therapeutic effects at both the cellular and animal levels, research on their transformation and clinical application is seriously insufficient, which is represented in Table 1

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SARS-CoV-2 spike proteins and cell-cell communication induce P-selectin and markers of endothelial injury, NETosis, and inflammation in human lung microvascular endothelial cells and neutrophils: implications for the pathogenesis of COVID-19 coagulopathy

Araujo, L., Khim, P., Mkhikian, H., Mortales, C

For instance, circ-cIARS binds to ALKBH5, an RNA-binding protein that negatively regulates ferritinophagy and ferroptosis, thereby blocking its activity (Ou et al., 2022)