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Conversely, insulin has much greater affinity for InsR than for IGF1R [16]

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This raises an intriguing possibility that other transcriptional regulators are involved that facilitate cellular adaptation when oxygen tension is limiting for HIF- 1

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Mice bearing orthotopic xenografts of NTRK2 -KO DIPG in the brainstem or NTRK2 -KO paediatric cortical glioblastoma in the frontal cortex exhibited a marked increase in overall survival compared with littermate controls xenografted with NTRK2 wild-type cells (Fig