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Sappanone a alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis via activating the SIRT1/Nrf2 signaling pathway

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doi: 10.1073/pnas.0914036107

In our study, physiological and biochemical responses were significantly enhanced under arsenic stress, and brassinosteroids (BRs) played a crucial role in further strengthening these responses by modulating antioxidant defense, nutrient balance, and stress tolerance mechanisms 41

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We confirmed that GCLC-KO mice have significantly reduced GCLC and glutathione levels, and an elevated ratio of oxidized to total glutathione in their brains (Fig