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It is interesting to mention that the placentae of women with SLE and APL syndrome show higher classical CS pathway activation, including higher C4d (a most important classical CS pathway activation marker) expression at the feto-maternal interface, leading to fetal loss and preeclampsia development, than normal healthy pregnant women (408, 419, 420)

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C2 is 20-fold more selective at human FFAR2 than at human FFAR3, while it is equipotent at both mouse orthologs

The role of active oxygen species and lipid peroxidation in the antitumor effect of hyperthermia

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doi: 10.1111/raq.12416 364 ZhangL