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Oxidative stress is also reported to be an important pathological phenomenon that begins to appear early in the course of AD ( Gpx4 KO mice showed obvious defects in spatial learning and memory function, while ferroptosis inhibitor Lip-1 could ameliorate the neurodegeneration in these mice ( Therapeutically, iron chelator desferrioxamine has already been conducted a clinical trial in AD in 1991 ( HD HD is an autosomal dominant neurodegenerative disease caused by the CAG repeat length mutation in the huntington gene ( huntington may cause oxidative stress and neurotoxicity to the neurons in corpus striatum ( Some characteristics of ferroptosis have been observed in HD patients and experimental animal models, such as iron accumulation ( Discussion Since ferroptosis was defined in 2012, the research on its mechanisms and clinical applications has been a hotspot

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Overall, KD shows promise as a complementary therapeutic strategy capable of targeting multiple aspects of PD pathology