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GIP receptor activation may further support insulin secretion and may enhance weight-loss effects when combined with GLP1 activity

Semaglutide 2.4mg (GLP-1 Agonist): Proven GLP-1 effects (appetite suppression, gastric emptying) Already FDA-approved as Wegovy Established safety profile Cagrilintide 2.4mg (Amylin Analog): Mimics amylin, a hormone co-secreted with insulin Slows gastric emptying through different pathway than GLP-1 Reduces appetite through hindbrain (not hypothalamus) Improves postprandial glucose The Advantage: Leverages proven semaglutide efficacy and safety, adds complementary amylin effects

Data collected during the probe trials time spent in the target quadrant and entries into the target quadrant) were also analyzed using one-way One-way ANOVA was used to analyze the dendritic spine results and significant effects were analyzed by Tukey post-hoc test

Funding The author(s) declare that financial support was received for the research, authorship, and/or publication of this article