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Crucially, they demonstrated that Vitamin B12 supplementation successfully regulates this hyperinflammation through epigenetic mechanisms, showing immense promise for reversing Long COVID-induced neuroinflammation and cognitive decline

The HadCM3 results are also in agreement with Dalaiden et al

References: Wu G, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004;134(3):489-492. doi:10.1093/jn/134.3.489

Increased Hcy levels were linked to poorer cognitive performance in female PwPD (Bakeberg et al

What is the difference between a randomized controlled trial and a cohort study

Initial clinical trials only tested a gap of less than six months between doses, but unexpected popularity and resulting shortages caused further testing to validate wider spacing of the two doses