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Mendias CL, Enselman ERS, Olszewski AM, Gumucio JP, Edon DL, Konnaris MA, et al

183 Although no rigorous randomized controlled trials have shown estriol to be safer or more effective than estradiol, 184 some physicians experienced in prescribing compounded hormones prefer transdermal formulations comprising primarily estriol (eg, Bi-Est)