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Subsequently, M2 macrophages, which exhibit anti-inflammatory and repair characteristics, release growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), IGF-1 and TGF- to promote tissue repair (74)

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This prevents the binding of fibrin to plasmin and preserves and stabilizes the matrix structure of fibrin and diminishes the ability of plasmin to lyse fibrin clots