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Azoles are frontline antifungal compounds used in crop protection and in human and animal health (207, 208)

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Dysregulation of SQOR has been implicated in mitochondrial diseases 52 , neurodegenerative disorders 53 and ischemiareperfusion injury 48 , highlighting its broader importance in mitochondrial redox metabolism

Monoclonal antibodies targeting PD-1 (such as pembrolizumab and nivolumab), PD-L1 (such as atezolizumab) and CTLA-4 (such as ipilimumab) have demonstrated robust clinical activity by reinvigorating antitumor immunity