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Activated M1 macrophages engulf and destroy microbes, eliminate damaged cells (e.g., tumor cells and apoptotic cells), present antigens to T cells for increasing the adaptive immune response, and produce high levels of pro-inflammatory cytokines (e.g., IL-1, IL-6, and IL-23), Reactive Oxygen Species (ROS), and Nitric Oxide (NO), as well as activate other immune and non-immune cells

doi: 10.1016/S0047-6374(00)00217-7

It is produced primarily in the liver and is involved in many critical biological functions in the body including metabolism of toxins, immune system function, protection against oxidative cell damage, and recycling of vitamins E and C

J neurology neurosurgery Psychiatry

Analysis of neocortex in three males with the fragile X syndrome

E.NachmanS.ReadS