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Misell LM, Lagomarcino ND, Schuster V, Kern M

Finally, laboratory and animal tests showed that FM causes DNA damage, which stops the cell cycle and regulates glutathione metabolism to inhibit the p53/xCT/GPX4 pathway, thereby inducing ferroptosis and suppressing liver cancer progression ( FIGURE 1 The development of cancer therapeutic drugs is entering a new era of precision and personalization

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the Postgraduate Research & Practice Innovation Program of Jiangsu Province (grant number KYCX17_1296)

Through the analysis of clinical data of LAC patients, the expression of PD-L1 in tumours in the TP53/KRAS comutation group was increased, and the proportion of CD8 + T cells in TME was higher, which was consistent with the clinical benefit of TP53, KRAS or TP53/KRAS-mutated cancer patients after treatment with PD-1 inhibitors 113

doi: 10.1016/j.jinorgbio.2011.11.002