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Its plasma levels decline significantly with age (from ~200ng/mL at 20 to ~80ng/mL at 60), making it a key compound for aging biology and regenerative research

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An experimental study in the rat, Scand

This brief liberation of copper ions triggers a localized inflammatory response, including histamine release that causes the redness and itching many users experience

This is an extreme scenario that proper dosing and monitoring makes virtually impossible

It is most often studied in animal models of tendon, gut, and vessel injury, and is not an FDA-approved drug