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Materials and methods Ethic statements The animal studies were carried out in strict accordance with the Detailed Rules for the Administration of Animal Experiments for Medical Research Purposes issued by the Ministry of Health of the Peoples Republic of China and were approved by the Animal Experiment Administration Committee of The Fourth Military Medical University

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The following frequency information is used to assess side effects

The sample was redissolved in 100 L of ice-cold 50% methanol, centrifuged again, and filtered through a 0.22-m membrane to obtain the test solution

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