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Regional and cellular pathology in frontotemporal dementia: relationship to stage of disease in cases with and without Pick bodies

In agreement with this, we observed significantly decreased levels of choline, and alterations in the metabolites of both branches of the Kennedy pathway (phosphocholine, CDP-choline, phosphoethanolamine, CDP-ethanolamine)

It has been observed that Polo-like kinase 1 (PLK 1) is suppressed in septic rats, leading to reduced expression of IB- and enhanced nuclear translocation of NF-B p65