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Carrier-Mediated Transport (CMT) CMT of small molecules across the BBB occurs after the interaction between a substrate compound and the specific transport protein, which can be expressed in either the luminal or abluminal membrane or both sides of the brain capillary endothelial cells (Table I)

Data were compared between pre- and post-VLCD groups in the obese cohort

Currently, there is an increasing focus on therapeutic strategies targeting the side branches of glycolysis, especially the serine/glycine (ser/gly) synthesis pathway, since it is upregulated in approximately 30% of all cancers, including GBM [21]

Furthermore, epigenetic dysregulation has been described in neurodegenerative models, including alterations in chromatin structure and histone acetylation that influence gene expression linked to metabolic stress responses and neuronal survival [9]

Anticancer Drugs , 30 , 241250

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