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Due to limitations in chemical synthetic drug research, the focus has shifted towards developing herbs based on natural substances

The absence or presence of publication bias was confirmed through the Eggers test, as shown in Table 1

It functions as a nonselective melanocortin receptor agonist and is widely studied in preclinical research involving pigmentation pathways, receptor pharmacology, and neuroendocrine signaling

Exp Neurol 161(2):50316 Chmielarz P, Saarma M (2020) Neurotrophic factors for disease-modifying treatments of Parkinsons disease: gaps between basic science and clinical studies

Some peptides have compelling preclinical and mechanistic data, although rigorous human clinical evidence supporting their use for longevity remains limited