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[] The endogenous opioid system mediates, at least in part, the pathogenesis of pruritus of cholestasis, [] thus, this indicates that there is a complex regulatory relationship in the eyes, brain, liver, and the skin

Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk (11th ed.)

USA 118 , e2106017118 (2021)

Cooper J, Bokmeyer T, Bowles W

They found rats treated with CAPE had significantly less histologic alterations, lower ALT and AST levels, suggesting CAPE could protect against radiation-induced liver damage [47]

Sleep and Stress Management: Their Impact on Skin Tone When you dont sleep enough and always feel stressed, it makes your skin look dull and causes wrinkles, breakouts, dark under-eye circles, and saggy cheeks