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2004]Review Human pineal physiology and functional significance of melatonin

However, a potentially transformative approach is being advanced to create axon guidance paths via factors secreted by host cells transfected with precise spatial precision (via stereotaxic microinjection) to overexpress growth factors, creating chemotaxic gradients to drive long-distance, targeted axonal outgrowth from endogenous and/or transplanted cells in the CNS

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(PubMed) Li S, Chen X, Li Q, et al