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Insulin resistance in adipose tissue, which is often related to obesity, compromises the inhibitory effects of insulin on adipose tissue lipolysis, leading to increased free fatty acids (FFAs) in portal circulation 4,5,6

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doi: 10.1021/acs.biochem.7b00199 41

Central to both reduction and oxidation pathways is the protein disulfide isomerase (PDI) family of enzymes (Ellgaard and Ruddock 2005) that are capable of exchanging disulfides with their substrate proteins (Fig

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