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Consistently, hypoxia-induced AR/SDH activity is cytoprotective: AR upregulation under hypoxia helps prevent cell death, whereas AR inhibition reduces HIF-1 accumulation and impairs survival signaling (10, 13)

P.UsiskinK.EdwardsR.DesaiM.LawG.et al (2016)

Iron overload induces a significant increase in ferritin expression and leads to iron dependent death

Third-party testing documentation

Owing to the limited size and availability of myocardial biopsy specimens, multiple sections were prepared from a single FFPE tissue block for each case, and 3-4 ROIs were selected per case