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Multi-session protocols over weeks or months are where any meaningful skin tone parameter change tends to emerge and even then, the effect is modest for most patients

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It would certainly be preferable that GSHee be delivered in a dose form that would not elicit profound responses prior to administration of an opioid and we are establishing whether lower doses or a constant infusion can achieve blockade of fentanyl-induced OIRD without eliciting dramatic effects on ventilation prior to administration of the opioid