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Meanwhile, tumor cells can increase FAO levels by upregulating CPT1 expression, and high levels of FAO can promote EMT [100, 132, 133] and foster M2 macrophage polarization, which subsequently leads to the secretion of pro-inflammatory cytokines such as IL-1, thereby augmenting tumor cell motility and proliferative capacity [134]

ng ch i "ng lc", hy bt u bng "k lut" v s la chn thng minh

Laryngoscope 122: 19791987

Mi hng tng i nh, nhanh chng bay i, khng lm t mi nc hoa m mnh s dng

However, the recovery of these regenerative capabilities (by increased expression of NAMPT for example) change the physiology of the cells towards stem-like cells, gaining some cancer properties, such as unlimited proliferative capacity, altered metabolism, DNA-repair, methylation alterations, with phenotype similar to CSCs, which deregulation by any other mutation initiate the tumor

[PubMed] [CellPress] 92