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Preclinical Evidence Comparison Multiple independent preclinical and in vitro studies have confirmed the significant advantages of SAG in terms of bioavailability

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Wu H, Li M, Shao X, An Z, Du J, Yin H, et al

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Notably, while S1PR2 is upregulated and induces the internalization of meningococci, the activation of S1PR1 or S1PR3 reduces the number of intracellular bacteria (Fohmann et al., 2023)