glutathione h2o2 1: Detoxification of oxidizing species. Hydrogen peroxide is reduced to Glutathione in Cellular Redox Homeostasis:

Besides, disruption of MTR reaction leads to insufficient supply of methionine and S-adenosylmethionine (SAM), which is essential for the myelination of myelin sheath, phospholipids and neurotransmitter synthesis, for maintaining brain and nervous system function.51 Furthermore, high levels of homocysteine due to vitamin B 12 deficiency are associated with an increased risk of atherosclerotic vascular disease, and this in turn may increase the risk of cognitive impairment or dementia

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A Canadian study published in JAMA found that people with diabetic kidney disease experienced faster decline in kidney function when given high doses of B12 and B6 compared to those who received a placebo

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