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Acute toxicity studies show good tolerability even at high doses, while chronic toxicity studies reveal mild hepatotoxicity and nephrotoxicity only at supratherapeutic levels

Individuals at high risk of developing CKD often have a history of ischemic heart disease, diabetes, or hypertension (Vallianou et al

Oswald MCW, Garnham N, Sweeney ST, Landgraf M (2018) Regulation of neuronal development and function by ROS

doi: 10.3389/fmars.2022.788455 37 StadtlanderT.FrsterS.RosskothenD.LeiberF

This raises an intriguing question of whether alternative sources of energy, such as ketone bodies by-passing the glycolytic pathway, might lead to increases in energy, and indeed some studies showed a reduction in fatigue in ME/CFS on a ketone diet [80]

The dose and duration will vary depending on your health needs, age, and dietary intake