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While these findings highlight the multifaceted benefits of NAC, it is imperative to note that the current body of research may not fully encapsulate the complex role of NAC in osteogenesis by regulating the stem cells and precursor cells in bone microenvironment

Notch signaling is also elevated in human bone during aging, 226 and loss of Notch signaling increases the number of skeletal stem and progenitor cells and improves the skeletal aging phenotype

journal cancer 134 , 15171528, (2014)

Chemokines stimulate bidirectional migration of human mesenchymal stem cells across bone marrow endothelial cells

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