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The Effect of Cinacalcet on Calcific Uremic Arteriolopathy Events in Patients Receiving Hemodialysis: The EVOLVE Trial

The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock

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Indeed, expression of senescent markers -gal, p21, p16, Bcl-2, Bcl-w and Bim was markedly reduced in Mdr2-/-Thy-1-/- and Mdr2-/- mice, while proliferation markers Ki67, Cyclin D, phospho-Akt were upregulated (vs Mdr2-/- or Mdr2-/-Thy-1-/- mice), suggesting that genetic deletion of Muc16 (which serves as a signal transduction receptor of Msln) and Msln prevents hepatocyte senescence in Mdr2-/- mice

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