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10.3389/fmed.2021.756940 121

71 In addition, extra-mitochondrial localization of branched-chain -keto acid dehydrogenase (BCKDH), a rate-limiting enzyme in BCAAs metabolism, has been reported in type 2 diabetic rat model (OLETF)

GSH serves a vital role in the system xc/GSH/GPX4-dependent antioxidant defense pathway during ferroptosis, and it is essential for the maintenance of normal GPX4 activity (66,67)

Conversely, when SS is associated with other autoimmune disorders, it is referred to as secondary Sjgrens syndrome (sSS) [6]

E on renal function parameters When compared to the controls, the single-dose injection of DOX resulted in considerably higher levels of creatinine, urea, and uric acid by 3.61, 1.01, and 1.31 times, respectively, and significantly lower levels of albumin by 0.68 times ( Table 2 )