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Folate deficiency may exert pro-inflammatory signaling by enhancing the monocytemacrophage system, and the production of the inflammatory mediators, IL1, IL6, TNF, and MCP1, and monocytes were significantly increased when folate deficiency (71)

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While data showed that ABX altered the microbial structure, the depletion efficiency was not verified by absolute quantitative metrics like 16S copy number qPCR or colony counting, leaving the intensity of the low-biomass background somewhat uncertain (Xu et al., 2025)

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