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Description

Under physiological conditions, the enzyme produces transient single-strand breaks in DNA and binds covalently to the 3-phosphoryl end of DNA at the break site through a tyrosine residue at position 723 in the COOH-terminus

Cell media was replaced daily with media supplemented with the indicated drugs

coli n = 17, P

Acknowledgments Figures 1, 4, and S5 were created using the FigureLabs AI platform ( accessed on 27 March 2026)

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