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815 IFN- enhances the expression of Nrf2 and manganese-dependent superoxide dismutase in Friedreichs ataxia cells, activating the non-canonical Nrf2 pathway via p21

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The aims of this review are (1) to provide an overview of the clinical and biological overlap between neuropsychiatric long COVID and other fatigue-associated neuropsychiatric disorders, (2) to examine the shared molecular mechanisms of fatigue and depressive symptoms involving acetylcarnitine metabolism, and finally (3) to review the current evidence on acetylcarnitine supplementation studies as a treatment for fatigue-associated syndromes and pharmacological aspects of acetylcarnitine supplementation to provide a conceptual foundation for acetylcarnitine supplementation in neuropsychiatric long COVID syndrome

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Both HO-1 and NQO1 exhibit potent antioxidant effects, contributing to cellular protection 13,14