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One placebo-controlled, double-blind, cross-over trial in 86 subjects with fertility issues found that supplementation with L-carnitine (2 g/day) for two months improved sperm quality, as evidenced by increases in sperm concentration and motility (111)

Recent investigations have shown that trigonelline, a compound extracted from the plant fenugreek, can obstruct FMO3, thereby preventing the conversion of TMA to TMAO (87)

L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism

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Luteolin potentiates the sensitivity of colorectal cancer cell lines to oxaliplatin through the PPARgamma/OCTN2 pathway

The guanylate cyclase C agonist linaclotide ameliorates the gut-cardio-renal axis in an adenine-induced mouse model of chronic kidney disease