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in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis ( 3.2.3 Role of lipid peroxidation in coronary heart disease ACSL4, a key upstream regulator of lipid peroxidation, has garnered significant attention for its role in ferroptosis

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