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Acute As intoxication

This enzyme is found exclusively in the mitochondrial matrix [21]

Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1-mediated glycolytic reprogramming

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Specifically, GDH1 deletion led to decreased binding of Sir2 protein on the telomeres, causing elevated transcript levels of genes affected by the loss of the SIR complex [40]