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Authors contributions Conceptualization and methodoloy preparation, project administration, writing original draft: Kobayashi H Software preparation: Kobayashi H, Matsubara S, Yoshimoto C, Imanaka S Validation: Yoshimoto C, Shigetomi H, Imanaka S Formal analysis and investigation: Matsubara S, Yoshimoto C, Shigetomi H, Imanaka S Resources provided and supervision: Matsubara S Data curation: Matsubara S, Kobayashi H Writing, review, editing and visualization: Kobayashi H, Matsubara S, Yoshimoto C, Shigetomi H, Imanaka S Funding acquisition: Yoshimoto C Availability of data and materials Not applicable

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Proinflammatory cytokines serve as pivotal drivers of aging by initiating dysregulated inflammatory cascades, disrupting immune homeostasis, and triggering metabolic dysfunction, with their pathological effects manifesting across multiple biological scales, from subcellular processes to systemic pathophysiology

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Epitalon, a synthetic tetrapeptide from the Khavinson bioregulator program, activates telomerase to maintain telomere length -- addressing one of the primary hallmarks of aging