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Compared with the WT + Saline group, the levels of BUN, CREA, KIM-1, and NGAL, and the severity of renal tubular damage significantly increased in the WT + Cis group ( Figures 7A, B, E ), indicating the successful induction of cisplatin-induced mice model of AKI

A critical element in this process is the remodeling of the TME, the dynamic milieu surrounding cancer cells, which includes immune cells, stromal fibroblasts, extracellular matrix (ECM), blood vessels, and signaling molecules [126]

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