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Triplicate measurements were made and the s.d

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Once the tumours reached a volume of 50100 mm 3 , the mice were randomly assigned to one of four treatment groups: vehicle, IKE (30 mg kg 1 , intraperitoneally, once daily), LM10 (200 mg kg 1 , per os (p.o.), once daily), epacadostat (300 mg kg 1 , p.o., once daily) or a combination of treatments as indicated