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Description

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doi: 10.1159/000267522 136 ChaussDBrennanLABakinaOKantorowM

Aspartate kinase-independent lysine synthesis in an extremely thermophilic bacterium, Thermus thermophilus : lysine is synthesized via -aminoadipic acid, not via diaminopimeric acid

The model expresses full-length human ATXN3 with 84 glutamine repeats throughout the brain, capable of reproducing clinical features of SCA3 including locomotor deficits, cerebellar neuronal loss and progressive cerebellar degeneration