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Spinal melanotic schwannoma: a tumour with poor prognosis

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Is the acetate salt of a synthetic cyclic heptapeptide with the sequence cyclo-(Ac-Nle4-cyclo[Asp5-His6-D-Phe7-Arg8-Trp9-Lys10])-NH2, representing a conformationally constrained, metabolically stabilised derivative of the -MSH(4-10) pharmacophore core in which the Asp5 and Lys10 side chains are bridged by a lactam bond to form the cyclic backbone, Nle4 replaces methionine to prevent oxidative inactivation, and D-Phe7 replaces native phenylalanine to confer endopeptidase resistance and stabilise the receptor-binding pharmacophore conformation

El aumento en el nmero de melanocitos, o de la cantidad de melanina producida por esas clulas, suele conducir a un aumento clnicamente visible de la pigmentacin

Although melanotic schwannomas have historically been considered as rather benign lesions, the 2021 WHO classification of central nervous system tumors defines MMNSTs as a potentially aggressive entity ( MMNSTs often harbor PRKAR1A mutations, particularly in patients with Carney complex ( Despite their classification as malignant, MMNSTs exhibit variable clinical behavior, ranging from indolent locally controlled disease to aggressive tumors with distant spread