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Naringenin (Nar), a bioactive flavanone compound, activates the AMPK/SIRT1 signalling pathway, restoring mitochondrial Ca 2+ and decreasing ROS production as well as upregulating eNOSactivity, increasing NO production, and improving ED (Li et al., 2021)

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TABLE 2 Concentrations of constituents and metabolites determined after single (S) or multiple (M) intake of Pycnogenol by human volunteers (70) or patients ( *Pilot investigation with one participant

Methods Enzymol 252:3853 Vargas MR, Johnson JA (2009) The Nrf2-ARE cytoprotective pathway in astrocytes

NIACINA (VITAMINA B3) La vitamina B3, tambin conocida como niacina, cido nicotnico o nicotinamida es una vitamina hidrosoluble que forma parte de las dos coenzimas ms importantes que el organismo utiliza para la obtencin de energa: nicotinamida adenina dinucletido (NAD) y nicotinamida adenina dinucletido fosfato (NADP)