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J Biol Chem 265:2043720442 Downward J, Graves JD, Warne PH et al (1990) Stimulation of p21ras upon T-cell activation

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Recent research supports a prion-like propagation model, where pathogenic -synuclein spreads trans-neuronally via exosomes and synaptic transmission, initiating a chain reaction of misfolding across interconnected brain regions