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Many older dogs gain weight as activity levels drop, which strains already-vulnerable joints

2022;82:202131 e5

Int J Neurosci

Lactylation, a novel PTM involving the covalent conjugation of lactate moieties to histone lysine residues, exists in both enzymatically catalyzed and non-enzymatic forms (Li et al

de SimoneGDanielsSRDevereuxRBMeyerRARomanMJde DivitiisOet al

Landree LE, Hanlon AL, Strong DW, Rumbaugh G, Miller IM, Thupari JN, Connolly EC, Huganir RL, Richardson C, Witters LA, Kuhajda FP, Ronnett GV: C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism